Functional transplantable B-cells generated from mice
Stem cells generated from mice have shown to be functional when transplanted, leading to the possibility of future therapies… Functional B1-cells that have been derived from mouse embryonic stem cells have been found to be capable of long-term engraftment as they secrete natural antibodies after transplantation. Scientists were interested in B1-cells generated from pluripotent stem cells because they could be tested as a therapeutic for a broad range of immunological disorders. “It is still challenging to produce transplantable immune cells from mouse embryonic stem cells, so obtaining transplantable functional B1-cells from mouse embryonic stem cells is a significant advance in the field,” said senior study author Dr Momoko Yoshimoto of the Center for Stem Cell & Regenerative Medicine at the McGovern Medical School at UTHealth in Houston. “The take-home message is that a portion of immune cells may be replaced by cell therapies utilising pluripotent stem ce...